Reference Range. Levels higher than 10 mg/dL … Reference ranges for lipoprotein (a) (Lp[a]), a type of low-density lipoprotein (LDL), vary, being dependent on assay and reporting laboratories.
However, including these patients may much accord with actual clinical situations; such investigations regarding serum anti-PLA2R …
Among the 77 patients with PMN and available serum and/or biopsy, 69 (89.6%) had PLA2R-related disease as shown by anti-PLA2R-Ab and/or PLA2R-Ag, while 8 patients (8/77, 10.4%) were negative for both. Feb. 25, 2008 -- A new blood test may be able to predict heart disease in people with normal LDL cholesterol levels.. Our subsequent subgroup analyses included only patients with nephrotic-range proteinuria before immunosuppressive therapy at renal biopsy, a more homogeneous group (I 2 = 0.00%): serum anti-PLA2R testing performed well (AUC = 0.82) (Table 3). After 6 months, 29 patients (56.9%) cleared circulating anti-PLA2R, while in remaining 22 (43.1%), they persisted.
Anti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy.
A request for this test on ICE will also generate a label for a TSP7a which is performed in Renal Research Laboratory MFT.
A recently published study by Feng et al (2014) demonstrated gender-specific differences in reference intervals of serum Lp-PLA 2 levels in 763 healthy Chinese Han subjects, with significantly lower serum levels in females compared to males (75th percentile: female 489 U/L (18-49 years) resp. It's becoming clear that your cholesterol level doesn't tell … As many as 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R. Positive serum anti-PLA2R antibody and glomerular PLA2R deposition were seen in 58.8% (80/136) and 95.6% (130/136) patients, respectively (P < .001). Anti-PLA2R levels respond to immunosuppression often showing an immunological remission (anti-PLA2R in normal range) 3-6 months ahead of remission of proteinuria where this occurs.
PLA2R : Membranous nephropathy (MN) is a rare disease in which immune complexes deposit at the glomerular basement membrane, causing damage to the filtration barrier, resulting in proteinuria. May also include abnormal ranges.
They also differ by population and may vary regionally worldwide. Reference Ranges. Background To discuss the clinicopathological features and prognosis of patients with idiopathic membranous nephropathy (IMN) who are serum-negative for the anti-PLA2R antibody.
Method Overall, 229 IMN patients were retrospectively collected in this study and classified into anti-PLA2R antibody-negative (PLA2R−, 59 cases) and antibody-positive (PLA2R+, 170 cases) groups. May also include abnormal ranges.
542 U/L (50-88 years), and males 579 U/L (18-87 years). Reference Interval Normal range/expected value(s) for a specific disease state.
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